CD37 — CD37 molecule
CD37 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CD37's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | B cell identity B cell maturation | C12orf42, DRAM2, GNG7, ITM2B, PRICKLE1, RBMS1, SAV1, TNFRSF13C | View in SCUBA |
| CD4⁺ T cells | Leukocyte adhesion signaling migration & adhesion | ARHGDIB, BIN1, DGKA, DGKZ, EIF3F, EIF3L, EIF4B, GYPC +22 more | View in SCUBA |
| CD8⁺ T cells | TCR Complex Signaling TCR Signaling | ACAP1, ANXA1, CD3E, CITED2, DUSP1, EVL, LAPTM5, LCK +4 more | View in SCUBA |
| Innate lymphoid cells | NK/ILC1 Identity Differentiation | ABCA5, ARHGAP15, CD96, CD99, CTSD, EPC1, GIMAP2, GIMAP6 +17 more | View in SCUBA |
| Macrophages | Fc Receptor Phagocytosis Lysosomal & pahgocytosis | ANXA6, C1orf162, FCGR1A, FCGR3A, FPR1, GCA, HNMT, HTRA1 +10 more | View in SCUBA |
| Mucosal-associated invariant T cell | T cell Surface Signaling TCR Signaling | ICAM3, LIME1, MFNG, MZT2A, NAA10, PLSCR3, SIGIRR |
About the gene
| Synonyms | TSPAN26 |
|---|---|
| Chromosome | 19: 49335171-49343335 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | CD markers, Predicted intracellular proteins, Predicted membrane proteins |
Function
Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling. Participates thereby in diverse biological functions such as cell signal transduction, adhesion, migration and protein trafficking. Upon ligand binding, two signaling pathways are activated, one acting through phosphorylation by LYN leading to cell death or a survival pathway with activation of GSK3B. Plays an essential role essential for clustering of integrin ITGA4/ITGB1 and promotes its mobility in the plasma membrane of B-cells. In turn, participates in ITGA4/ITGB1 integrin-mediated antiapoptotic signaling through AKT (By similarity). Also plays a role in the migration of dendritic cells and neutrophils to draining lymph nodes, as well as in their integrin- mediated adhesion (By similarity). Negatively regulates IL-6 responses through direct interaction with SOCS3 thereby preventing constitutive IL-6 signaling. Alternatively, inhibition of IL-6 signaling can also occur via interaction and stabilization of DECTIN1/CLEC7A at the cell membrane to inhibit its ability to promote the production of IL-6.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.