FCGR2A — Fc gamma receptor IIa
FCGR2A belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
FCGR2A's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Macrophages | Monocyte Phagocytic Identity Lysosomal & pahgocytosis | CD14, CD99, CMTM3, DUSP3, FLOT2, INF2, MARVELD1, PLAU +7 more | View in SCUBA |
| Monocytes | Fc Receptor Activation Innate immunity | ARID5A, CD300E, CREM, GLUL, LCP2, OLR1, PLSCR1, TRIM25 | View in SCUBA |
| Neutrophils | Bacterial Phagocytosis Program Phagocytosis | CASP4, CLEC7A, CSF2RB, CSF3R, CYTH4, LY96, SLC11A1, SLC25A37 +1 more |
About the gene
| Synonyms | CD32, CD32A, CDw32, Fc-gamma-RIIa, FCG2, FcgammaRIIa, FCGR2, FCGR2A1, IGFR2 |
|---|---|
| Chromosome | 1: 161505430-161524013 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | CD markers, FDA approved drug targets, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | IgG-binding protein, Receptor |
| Biological process | Immunity |
Function
Binds to the Fc region of immunoglobulins gamma. Low affinity receptor. By binding to IgG it initiates cellular responses against pathogens and soluble antigens. Promotes phagocytosis of opsonized antigens
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.