SCUBA

CD99 — CD99 molecule (Xg blood group)

CD99 belongs to a gene co-expression module in 14 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

CD99's module in each cell type

Cell typeModuleShares the module with
CD19⁺ B cellsER/vesicle trafficking
Protein processing & ER
ATP6V0B, DIAPH1, HCST, M6PR, MTDH, MTPN, REEP5, SCPEP1 +1 moreView in SCUBA
CD8⁺ T cellsGut Tissue Residency
Gut residence
ALOX5AP, C4orf3, CAPN2, CD164, CD3D, CD7, CLIC3, ID2 +9 moreView in SCUBA
EndothelialEndothelial NO Activation
Endothelial cell development
BCL6B, BLOC1S1, CDH13, COX5A, CREM, DDAH2, DDX46, EEA1 +8 moreView in SCUBA
FibroblastsTranslation Initiation
Housekeeping
CCNI, CNBP, EIF3E, EIF3F, ESD, HNRNPA1, ITM2B, LAPTM4A +3 moreView in SCUBA
Gamma-delta T cellsTCR Vesicular Trafficking
TCR Signaling
ARL2BP, ARL8A, ARRDC1, C18orf32, CCDC92, CD3D, CD3G, FKBP8 +14 more
Glial cellsGlial Cytoskeletal Homeostasis
Cytoskeletal
ARL6IP5, CNP, CSRP1, FEZ1, RHEB, SCCPDH, TBCB, VWA1View in SCUBA
Goblet cellsMitochondrial Metabolism
Mitochondrial & OxPhos
ATP5F1B, ATP5PB, COTL1, ECHS1, GPR160, HADH, PRDX3, SUCLG1 +1 moreView in SCUBA
Hematopoietic progenitor cellsMultipotent Progenitor State
Stemness
CD44, FLT3, GBP2, GLIPR1, IL6R, PLCB1, PRAM1, PROM1
Innate lymphoid cellsNK/ILC1 Identity
Differentiation
ABCA5, ARHGAP15, CD37, CD96, CTSD, EPC1, GIMAP2, GIMAP6 +17 moreView in SCUBA
Lymphatic endothelialProtein Quality Control
Protein processing & ER
BCAP29, CDC42, DYNLRB1, GNG5, NDUFV2, PDCD6, PFDN5, SKP1 +1 moreView in SCUBA
MacrophagesMonocyte Phagocytic Identity
Lysosomal & pahgocytosis
CD14, CMTM3, DUSP3, FCGR2A, FLOT2, INF2, MARVELD1, PLAU +7 moreView in SCUBA
MonocytesInflammatory Monocyte Activation
Inflammatory
ANG, ANXA2, IGFBP7, MGST1, PLAAT3, RNASE2, S100A10, ST14View in SCUBA
Mucosal-associated invariant T cellMAIT Tissue Residence
Tissue residence
ANAPC16, ARHGDIB, ATP5IF1, CD3E, CD53, CTSD, CXCR6, ECH1 +7 more
Smooth muscle cellsSMC focal adhesion
Migration & adhesion
ANXA6, ARMCX6, C1orf21, DNAJC1, HSBP1, KANK1, MORF4L2, PFDN1 +7 moreView in SCUBA

About the gene

SynonymsMIC2
ChromosomeX: 2691187-2741309
Predicted locationIntracellular, Membrane
Essential geneNo
Protein classCD markers, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins
Biological processCell adhesion

Function

Involved in T-cell adhesion processes and in spontaneous rosette formation with erythrocytes. Plays a role in a late step of leukocyte extravasation helping leukocytes to overcome the endothelial basement membrane. Acts at the same site as, but independently of, PECAM1. Involved in T-cell adhesion processes (By similarity)

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.