PLAU — Plasminogen activator, urokinase
PLAU belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PLAU's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Endothelial Lipid Signaling migration & adhesion | A2M, ADGRG1, ARHGEF15, CNOT6L, CYYR1, DIP2B, HIP1R, PCDH1 +3 more | View in SCUBA |
| Fibroblasts | Hypoxia Response Stress | ACSL4, AP2S1, ARFGAP3, C4orf48, EPAS1, HIF1A, IL4R, ISG20 +8 more | View in SCUBA |
| Macrophages | Monocyte Phagocytic Identity Lysosomal & pahgocytosis | CD14, CD99, CMTM3, DUSP3, FCGR2A, FLOT2, INF2, MARVELD1 +7 more | View in SCUBA |
| Monocytes | Monocyte Tissue Infiltration Migration & adhesion | CD59, CDCP1, FPR3, NRP1, NRP2, PDE4DIP, PMP22, PTMS +3 more | View in SCUBA |
| Neutrophils | Chemokine Secretion Cytokine & chemokine secretion | CXCL1, CXCL2, CXCL8, DDIT3, GADD45B, GLUL, HCAR2, IER5 +3 more | |
| Smooth muscle cells | Synthetic Matrix Phenotype ECM remodeling | APOE, CFD, GAS6, GJA1, MAP1LC3A, MXRA5, PHF14, POSTN +1 more | View in SCUBA |
About the gene
| Synonyms | UPA, URK |
|---|---|
| Chromosome | 10: 73909177-73917496 |
| Predicted location | Intracellular, Secreted |
| Essential gene | No |
| Protein class | Cancer-related genes, Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted secreted proteins |
| Molecular function | Hydrolase, Protease, Serine protease |
| Biological process | Blood coagulation, Fibrinolysis, Hemostasis, Plasminogen activation |
Function
Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.