Monocyte Phagocytic Identity
Gene co-expression module in Macrophages
| Category | Lysosomal & pahgocytosis |
|---|---|
| Genes | 16 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 16 genes have a known function matching the annotation |
Why this annotation
Key hub genes include FCGR2A (Fc-gamma receptor IIA, phagocytosis), CD14 (LPS co-receptor, monocyte marker), PLAU (urokinase plasminogen activator, tissue remodeling/migration), PLXND1 (semaphorin receptor, cell migration), FLOT2 (lipid raft signaling), DUSP3 (phosphatase regulating MAPK/immune signaling), CD99 (leukocyte diapedesis), PYGL (glycogen phosphorylase). FCGR2A and CD14 anchor this as a monocyte/macrophage phagocytic identity module. PLAU and PLXND1 add migratory character. Neighbor M32 is strongly inflammatory mono_mac, supporting this as a related monocyte identity/phagocytosis module.
Genes
CD14, CD99, CMTM3, DUSP3, FCGR2A, FLOT2, INF2, MARVELD1, PLAU, PLOD1, PLXND1, PTPRO, PYGL, RTL8C, SYT11, TLE5
Most correlated modules
- ER-Lysosome Trafficking · correlation 0.95
- Fc Receptor Phagocytosis · correlation 0.95
- Glycogen Metabolism · correlation 0.92
- Oxidative Metabolic Program · correlation 0.92
- Monocyte-Mac Iron Transport · correlation 0.92
- ER Protein Quality Control · correlation 0.91
- Central Carbon Metabolism · correlation 0.91
- Myeloid Immune Checkpoint · correlation 0.91
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.