FRMD8 — FERM domain containing 8
FRMD8 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
FRMD8's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Coagulation Protease Signaling Inflammation | CFDP1, F2RL3, HTRA1, ITIH5, ME3, PASK, PRSS23, STT3B +1 more | View in SCUBA |
About the gene
| Synonyms | FKSG44, FLJ90369, iTAP |
|---|---|
| Chromosome | 11: 65386621-65413525 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
Function
Promotes the cell surface stability of iRhom1/RHBDF1 and iRhom2/RHBDF2 and prevents their degradation via the endolysosomal pathway. By acting on iRhoms, involved in ADAM17-mediated shedding of TNF, amphiregulin/AREG, HBEGF and TGFA from the cell surface. Negatively regulates Wnt signaling, possibly by antagonizing the recruitment of AXIN1 to LRP6.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.