PASK — PAS domain containing serine/threonine kinase
PASK belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PASK's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Tfh program B cell help | BAZ2B, CCDC50, CDK5R1, CXCR5, IL6R, LY96, MTUS1, PIP4P2 +10 more | View in SCUBA |
| Endothelial | Coagulation Protease Signaling Inflammation | CFDP1, F2RL3, FRMD8, HTRA1, ITIH5, ME3, PRSS23, STT3B +1 more | View in SCUBA |
| Pericytes | Cytoskeletal Remodeling Cytoskeletal | ARHGAP18, F2RL3, FSCN1, IVNS1ABP, JUP, SEMA3F, TBCD, VWA1 | View in SCUBA |
About the gene
| Synonyms | KIAA0135, PASKIN, STK37 |
|---|---|
| Chromosome | 2: 241106099-241150264 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Predicted intracellular proteins |
| Molecular function | Kinase, Serine/threonine-protein kinase, Transferase |
Function
Serine/threonine-protein kinase involved in energy homeostasis and protein translation. Phosphorylates EEF1A1, GYS1, PDX1 and RPS6. Probably plays a role under changing environmental conditions (oxygen, glucose, nutrition), rather than under standard conditions. Acts as a sensor involved in energy homeostasis: regulates glycogen synthase synthesis by mediating phosphorylation of GYS1, leading to GYS1 inactivation. May be involved in glucose-stimulated insulin production in pancreas and regulation of glucagon secretion by glucose in alpha cells; however such data require additional evidences. May play a role in regulation of protein translation by phosphorylating EEF1A1, leading to increase translation efficiency. May also participate in respiratory regulation.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.