F2RL3 — F2R like thrombin or trypsin receptor 3
F2RL3 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
F2RL3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Coagulation Protease Signaling Inflammation | CFDP1, FRMD8, HTRA1, ITIH5, ME3, PASK, PRSS23, STT3B +1 more | View in SCUBA |
| Fibroblasts | Inflammatory Fibroblast Activation Inflammatory | ATP2A2, BAMBI, C5AR2, CRISPLD2, CSNK1E, CTNNB1, DLC1, ETS2 +11 more | View in SCUBA |
| Pericytes | Cytoskeletal Remodeling Cytoskeletal | ARHGAP18, FSCN1, IVNS1ABP, JUP, PASK, SEMA3F, TBCD, VWA1 | View in SCUBA |
About the gene
| Synonyms | PAR4 |
|---|---|
| Chromosome | 19: 16888999-16892606 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | G-protein coupled receptors, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | G-protein coupled receptor, Receptor, Transducer |
| Biological process | Blood coagulation, Hemostasis |
Function
Receptor for activated thrombin or trypsin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.