Coagulation Protease Signaling
Gene co-expression module in Endothelial
| Category | Inflammation |
|---|---|
| Genes | 10 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 5 of 10 genes have a known function matching the annotation |
Why this annotation
F2RL3 (PAR4, protease-activated receptor 4) is a thrombin/coagulation receptor expressed on endothelium. PRSS23 is a serine protease involved in vascular remodeling. HTRA1 is a serine protease that cleaves TGF-beta binding proteins and ECM components, modulating vascular homeostasis. ITIH5 (inter-alpha-trypsin inhibitor heavy chain 5) stabilizes ECM hyaluronan and is expressed in vascular contexts. STT3B mediates N-glycosylation of secreted/membrane proteins including coagulation factors. PASK is an energy-sensing kinase. ME3 (malic enzyme 3) supports metabolic flux. TBCD (tubulin cofactor D) and CFDP1/FRMD8 are less clearly linked. The module has a moderate inflammation signal and centers on protease/coagulation signaling.
Genes
CFDP1, F2RL3, FRMD8, HTRA1, ITIH5, ME3, PASK, PRSS23, STT3B, TBCD
Most correlated modules
- Vascular Barrier Integrity · correlation 0.85
- Basement Membrane Assembly · correlation 0.82
- Angiogenic Endothelial Identity · correlation 0.75
- Venous Endothelial Identity · correlation 0.72
- VEGF Tip Cell Signaling · correlation 0.70
- Arterial EC Identity · correlation 0.68
- CXCL12 Angiogenic Chemotaxis · correlation 0.62
- Venous EC Identity · correlation 0.60
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.