FZD6 — Frizzled class receptor 6
FZD6 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
FZD6's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Quiescent EC Identity Endothelial cell development | ADRB1, CAMK2D, CLU, CYP1B1, FAM20A, FOXP1, GCHFR, GIPC2 +19 more | View in SCUBA |
About the gene
| Synonyms | Hfz6 |
|---|---|
| Chromosome | 8: 103298433-103332866 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Disease related genes, G-protein coupled receptors, Human disease related genes, Potential drug targets, Predicted membrane proteins |
| Molecular function | Developmental protein, G-protein coupled receptor, Receptor, Transducer |
| Biological process | Wnt signaling pathway |
Function
Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Together with FZD3, is involved in the neural tube closure and plays a role in the regulation of the establishment of planar cell polarity (PCP), particularly in the orientation of asymmetric bundles of stereocilia on the apical faces of a subset of auditory and vestibular sensory cells located in the inner ear (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.