Quiescent EC Identity
Gene co-expression module in Endothelial
| Category | Endothelial cell development |
|---|---|
| Genes | 28 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 13 of 28 genes have a known function matching the annotation |
Why this annotation
This module is significantly downregulated with UC inflammation and partially restored with treatment, suggesting a homeostatic/quiescent endothelial program. Key genes include OCLN (occludin, tight junction integrity), ADRB1 (beta-1 adrenergic receptor, vascular tone), LEPR (leptin receptor, metabolic signaling), FZD6 (Wnt/Frizzled signaling), TMEM100 (BMP signaling in arterial ECs), CYP1B1 (vascular cytochrome P450), TLN2 (talin-2, integrin adhesion), PLCB4/CAMK2D (calcium signaling), MMP28 (homeostatic MMP), CLU (clusterin, cytoprotective). The combination of barrier integrity (OCLN), vascular tone receptors (ADRB1), and Wnt/BMP signaling suggests a quiescent vascular identity program lost during inflammation. Neighbor M142 also decreases with UC inflammation, supporting a shared homeostatic EC neighborhood.
Genes
ADRB1, CAMK2D, CLU, CYP1B1, FAM20A, FOXP1, FZD6, GCHFR, GIPC2, HSD17B12, HSPA2, INPP5K, KCTD12, LEPR, LGALS3, MET, MMP28, NRN1, OCLN, PDCD4, PDZD2, PLCB4, SMIM19, TLN2, TMEM100, TMEM43, TNKS1BP1, WLS
Most correlated modules
- Inflammatory ECM Remodeling · correlation 0.69
- Endothelial Barrier Homeostasis · correlation 0.68
- Arterial EC Identity · correlation 0.64
- Quiescent EC Identity · correlation 0.63
- Arterial EC Homeostasis · correlation 0.62
- Arterial EC Identity · correlation 0.61
- NF-κB Stress Signaling · correlation 0.54
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.