ADRB1 — Adrenoceptor beta 1
ADRB1 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ADRB1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Quiescent EC Identity Endothelial cell development | CAMK2D, CLU, CYP1B1, FAM20A, FOXP1, FZD6, GCHFR, GIPC2 +19 more | View in SCUBA |
| Gamma-delta T cells | Tissue Resident CD103+ Tissue residence | BCAS4, BLMH, CCNJL, CD160, CD96, CLIC5, CLNK, DHCR24 +28 more | |
| Natural Killer cells | Tissue-Resident NK Gut residency | CAMK4, GPR34, GPR55, ITGAE, LRRC25, MYO1E, NCR2, S100A13 +2 more | View in SCUBA |
About the gene
| Synonyms | ADRB1R |
|---|---|
| Chromosome | 10: 114043866-114046904 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | FDA approved drug targets, G-protein coupled receptors, Predicted membrane proteins, Transporters |
| Molecular function | G-protein coupled receptor, Receptor, Transducer |
Function
Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity. Mediates Ras activation through G(s)-alpha- and cAMP-mediated signaling. Involved in the regulation of sleep/wake behaviors.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.