G6PC3 — Glucose-6-phosphatase catalytic subunit 3
G6PC3 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
G6PC3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Macrophages | ER Stress UPR Stress | ANKRD9, APEH, ARMCX6, BET1L, CALR, CCDC107, COPS2, DNAJB11 +20 more | View in SCUBA |
About the gene
| Synonyms | UGRP |
|---|---|
| Chromosome | 17: 44070620-44082151 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted membrane proteins |
| Molecular function | Hydrolase |
| Biological process | Gluconeogenesis |
Function
Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. May form with the glucose-6-phosphate transporter (SLC37A4/G6PT) a ubiquitously expressed complex responsible for glucose production through glycogenolysis and gluconeogenesis. Probably required for normal neutrophil function.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.