ER Stress UPR
Gene co-expression module in Macrophages
| Category | Stress |
|---|---|
| Genes | 29 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 13 of 29 genes have a known function matching the annotation |
Why this annotation
The module is dominated by canonical ER stress and Unfolded Protein Response (UPR) genes: HSPA5 (BiP/GRP78, master UPR regulator), HSP90B1 (GRP94), PDIA3, PDIA4, PDIA6 (protein disulfide isomerases), DNAJB11 and DNAJB9 (ER-localized Hsp40 co-chaperones), CALR (calreticulin), MANF (ER stress-induced secreted factor), SDF2L1 (ER stress response protein), RPN2 (N-glycosylation machinery), and ESYT1 (ER-PM contact sites). G6PC3 and FUCA2 are also ER-resident enzymes. Despite all genes showing weak membership scores, the biological coherence of this gene set as an ER stress/UPR program is extremely strong. This likely reflects a macrophage ER stress state, possibly linked to high secretory demand or pathological ER stress in the gut.
Genes
ANKRD9, APEH, ARMCX6, BET1L, CALR, CCDC107, COPS2, DNAJB11, DNAJB9, ESYT1, FUCA2, G6PC3, HSP90B1, HSPA5, HYOU1, LCP1, MANF, PDIA3, PDIA4, PDIA6, RNF167, RPN2, SBDS, SDF2L1, SHB, SSR1, TESK1, VASP, YTHDF1
Most correlated modules
- Nuclear Pore Transport · correlation 0.93
- ER Protein Quality Control · correlation 0.92
- Ribosome Biogenesis · correlation 0.89
- Lysosomal Hydrolase Program · correlation 0.89
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.