DNAJB11 — DnaJ heat shock protein family (Hsp40) member B11
DNAJB11 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
DNAJB11's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | ER stress UPR Protein processing & ER | CCT2, CDK2AP2, CRELD2, DDX39A, DSTN, EIF5A, GPSM3, GTF3A +9 more | View in SCUBA |
| Endothelial | Actin Cytoskeletal Remodeling Cytoskeletal | ACTB, ACTG1, ARF1, ARPC5L, CFL1, CYCS, DNAJC1, ERLEC1 +5 more | View in SCUBA |
| Gamma-delta T cells | T Cell Phosphatase Signaling TCR Signaling | AMZ2, ASTE1, DR1, EFCAB2, IFIT3, PSMD14, PTPN7, SAR1A +4 more | |
| Macrophages | ER Stress UPR Stress | ANKRD9, APEH, ARMCX6, BET1L, CALR, CCDC107, COPS2, DNAJB9 +20 more | View in SCUBA |
About the gene
| Synonyms | EDJ, ERdj3, HEDJ |
|---|---|
| Chromosome | 3: 186567403-186585800 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Predicted intracellular proteins |
| Molecular function | Chaperone |
Function
As a co-chaperone for HSPA5 it is required for proper folding, trafficking or degradation of proteins. Binds directly to both unfolded proteins that are substrates for ERAD and nascent unfolded peptide chains, but dissociates from the HSPA5-unfolded protein complex before folding is completed. May help recruiting HSPA5 and other chaperones to the substrate. Stimulates HSPA5 ATPase activity. It is necessary for maturation and correct trafficking of PKD1.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.