ANKRD9 — Ankyrin repeat domain 9
ANKRD9 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ANKRD9's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Actin Vesicle Trafficking Cytoskeletal | ABRACL, ACTR3, ADRM1, C3orf14, CISD2, CLIC1, EIF2S1, ELOVL1 +10 more | View in SCUBA |
| Gamma-delta T cells | S-phase Proliferation Cell cycle | BCL6, COPS3, DCXR, ERRFI1, GMNN, GOLIM4, MTHFD2, OVCA2 +6 more | |
| Macrophages | ER Stress UPR Stress | APEH, ARMCX6, BET1L, CALR, CCDC107, COPS2, DNAJB11, DNAJB9 +20 more | View in SCUBA |
| Monocytes | G-protein Membrane Remodeling Migration & adhesion | ADA, CXCL16, DNMBP, EPB41L3, GFOD1, GNA12, GNA13, MRAS +7 more | View in SCUBA |
| Natural Killer cells | TGF-beta Response Immune regulation | AUTS2, CDK17, GNA13, MTFP1, N4BP3, RAB5IF, RBM38, TAMALIN +2 more | View in SCUBA |
About the gene
| Chromosome | 14: 102501767-102509799 |
|---|---|
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Biological process | Ubl conjugation pathway |
Function
Substrate receptor subunit of a cullin-RING superfamily E3 ligase complex (CUL5-based E3 ubiquitin ligase complex) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Depending of the metabolic state of the cell, promotes the proteasomal degradation of IMPDH2, the rate-limiting enzyme in GTP biosynthesis or protects IMPDH2 by stabilizing IMPDH2 filaments assembly. Implicated in different cellular processes, like copper homeostasis and cell proliferation.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.