CALR — Calreticulin

CALR belongs to a gene co-expression module in 17 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

CALR's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	mRNA Splicing RNA processing	AFF4, ARL6IP1, CCNL1, CLK1, DDX3X, DDX5, EIF4A2, HSPA5 +7 more	View in SCUBA
CD4⁺ T cells	NF-kB activation TCR/AP1/NFKb pathway	ABCF1, BCL2A1, BUD23, BZW2, CEBPZ, DDX21, DENND4A, GNL3 +21 more	View in SCUBA
CD8⁺ T cells	ER Protein Quality Control Protein processing & ER	ARPC3, DYNLL1, MRPL47, PDIA3, PPIB, PSMA5, PSMB1, PSMC4 +3 more	View in SCUBA
Endothelial	UPR / ER Stress Protein processing & ER	CANX, CTSB, CTTN, GRN, HDLBP, HSP90B1, HSPA5, HYOU1 +10 more	View in SCUBA
Enterocytes	ER chaperone/UPR Protein processing & ER	ANXA2, EFNB2, ENO1, HSP90B1, HSPA5, MARCKS, ME1, PDIA3 +3 more	View in SCUBA
Fibroblasts	ER-Golgi Trafficking Vesicular traficking	ARL1, COPE, DNAJC3, EMC7, GDI2, MPG, MYDGF, PDIA6 +6 more	View in SCUBA
Gamma-delta T cells	ER Glycoprotein Quality Control Protein processing & ER	APOL2, BAG6, ELP3, GBP1, GBP2, GBP4, HEXB, HSP90B1 +9 more
Glial cells	ER Translocon Activity Protein processing & ER	ARPC2, EDF1, MRPL52, MYL6, NDUFA1, OST4, PFN1, PPIB +3 more	View in SCUBA
Goblet cells	UPR Chaperone Response Stress	CRELD2, GMPPB, LRRC59, MANF, NUCB2, P4HB, PDIA3, PDIA4 +2 more	View in SCUBA
Hematopoietic progenitor cells	ER Protein Folding Housekeeping	ASRGL1, CD63, CHPT1, EMP3, GLUL, HSPA5, IDH2, MLEC +13 more
Innate lymphoid cells	Cytokine-driven Activation activation	BIRC3, CD69, DUSP5, GADD45G, ISG15, NCOA7, PPIF, RUNX3 +2 more	View in SCUBA
Macrophages	ER Stress UPR Stress	ANKRD9, APEH, ARMCX6, BET1L, CCDC107, COPS2, DNAJB11, DNAJB9 +20 more	View in SCUBA
Monocytes	ER Stress Response Stress	CSTB, CTNND1, HSP90B1, LPAR6, M6PR, MRPS6, PDIA6, PRDX1 +3 more	View in SCUBA
Mucosal-associated invariant T cell	NF-κB RNA Regulation RNA processing & translation	ARIH2, ATP1A1, BCLAF1, BNIP2, COG3, DDX6, EIF4G2, EIF4H +14 more
Natural Killer cells	NK Cytotoxic Activation Cytotoxicity	CDK6, FASLG, P4HB, PDIA3, PPIB, SLAMF7, STARD3NL, TIGIT +1 more	View in SCUBA
Pericytes	ER Chaperone UPR Stress	HSBP1, HSP90B1, PDIA3, PDIA6, PSMB5, RAB13, SSR4	View in SCUBA
Smooth muscle cells	ER Chaperone/UPR Protein processing & ER	CRISPLD2, FBLIM1, HIF1A, HSP90B1, HSPA5, IL6ST, OSMR, PCOLCE +3 more	View in SCUBA

About the gene

Synonyms	cC1qR, CRT, FLJ26680, RO, SSA
Chromosome	19: 12938578-12944489
Predicted location	Intracellular
Essential gene	No
Protein class	Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Transporters
Molecular function	Chaperone

Function

Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export. Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis (By similarity). Present in the cortical granules of non-activated oocytes, is exocytosed during the cortical reaction in response to oocyte activation and might participate in the block to polyspermy (By similarity).

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.