GBGT1 — Globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 (FORS blood group)
GBGT1 belongs to a gene co-expression module in 1 of 30 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
GBGT1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Colonocytes | BEST4+ Colonocyte Identity Epithelial development | ABI3BP, ADAMTS14, ADCY5, ANO7, ATOH8, BEST4, BMP2K, CA7 +33 more | View in SCUBA |
About the gene
| Synonyms | A3GALNT, FS, MGC44848, UDP-GalNAc |
|---|---|
| Chromosome | 9: 133152948-133163933 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Metabolic proteins, Predicted intracellular proteins |
| Molecular function | Glycosyltransferase, Transferase |
Function
Has lost the ability to synthesize Forssman glycolipid antigen (FORS1/FG). Might have acquired an alternative function in glycosphingolipid metabolism, but it remains to be established. It appears to have drifted more slowly than confirmed pseudogenes in the glycosyltransferase 6 family, suggesting that it has remained under evolutionary pressure.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.