GID8 — GID complex subunit 8 homolog
GID8 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
GID8's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Mitochondrial Translation Mitochondrial & OxPhos | ARF5, CBX6, CCDC124, CISD3, DCTN2, DDA1, EIF4E2, FKBP3 +17 more | View in SCUBA |
| Macrophages | Phagocytic Endolysosomal Lysosomal & pahgocytosis | ABHD2, ACTN4, AP3S1, ARF6, ATP6V1B2, CD151, CERS2, CNIH1 +27 more | View in SCUBA |
About the gene
| Synonyms | bA305P22.1, C20orf11, FLJ20602, TWA1 |
|---|---|
| Chromosome | 20: 62938147-62948475 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Biological process | Wnt signaling pathway |
Function
Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. Acts as a positive regulator of Wnt signaling pathway by promoting beta-catenin (CTNNB1) nuclear accumulation.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.