ATP6V1B2 — ATPase H+ transporting V1 subunit B2
ATP6V1B2 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ATP6V1B2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Lymphatic endothelial | Integrated Stress Response Stress | ATF4, HNRNPH3, PLEKHO1, PPP1R18, TGIF1, UBALD2, ZFAND5 | View in SCUBA |
| Macrophages | Phagocytic Endolysosomal Lysosomal & pahgocytosis | ABHD2, ACTN4, AP3S1, ARF6, CD151, CERS2, CNIH1, CPD +27 more | View in SCUBA |
| Neutrophils | Phagocytic Membrane Signaling Phagocytosis | APLP2, CD44, CDC42EP3, CLIC1, EFHD2, FCER1G, FLOT1, GRINA +9 more |
About the gene
| Synonyms | ATP6B2, HO57, VATB, Vma2, VPP3 |
|---|---|
| Chromosome | 8: 20197381-20226819 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Disease related genes, Essential proteins, FDA approved drug targets, Human disease related genes, Metabolic proteins, Predicted intracellular proteins, Transporters |
| Biological process | Hydrogen ion transport, Ion transport, Transport |
Function
Non-catalytic subunit of the V1 complex of vacuolar(H+)- ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. In renal intercalated cells, can partially compensate the lack of ATP6V1B1 and mediate secretion of protons (H+) into the urine under base-line conditions but not in conditions of acid load (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.