Phagocytic Endolysosomal
Gene co-expression module in Macrophages
| Category | Lysosomal & pahgocytosis |
|---|---|
| Genes | 36 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 11 of 36 genes have a known function matching the annotation |
Why this annotation
Hub genes include TCIRG1 (vacuolar ATPase subunit critical for lysosomal acidification and phagocytosis), AP3S1 (adaptor protein complex 3 for lysosomal targeting), ARF6 (endosomal/phagosomal trafficking), FMNL1 (actin nucleation in macrophage phagocytic cups), ITGB1 (integrin-mediated phagocytosis), QSOX1 (oxidoreductase), and cytoskeletal genes TPM4/ACTN4. The combination of lysosomal acidification machinery, actin remodeling factors, and vesicle trafficking components in mono_mac-enriched cells points to a phagocytic/endolysosomal program. SLC16A3 (lactate export) and CERS2 (ceramide synthesis) add metabolic context consistent with active phagocytes.
Genes
ABHD2, ACTN4, AP3S1, ARF6, ATP6V1B2, CD151, CERS2, CNIH1, CPD, FHOD1, FMNL1, GID8, GMFB, GOLT1B, HM13, ITGB1, LONP1, MBD4, MFSD12, MMP14, MPP1, NACC1, NRAS, NRBP1, PRELID3B, QSOX1, RAB1B, RDH11, SH3GLB1, SLC16A3, SLC43A3, SURF4, TCIRG1, TMCO3, TPM4, ZDHHC6
Most correlated modules
- Autophagy Lysosomal Regulation · correlation 0.96
- Actin Cytoskeleton Organization · correlation 0.96
- Monocyte Innate Signaling · correlation 0.95
- ER Protein Processing · correlation 0.94
- Hypoxia-driven Activation · correlation 0.93
- ER-Lysosome Trafficking · correlation 0.93
- Inflammatory Monocyte Activation · correlation 0.92
- RNA Processing Housekeeping · correlation 0.92
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.