ABHD2 — Abhydrolase domain containing 2, acylglycerol lipase
ABHD2 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ABHD2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | AKT survival signaling TCR/AP1/NFKb pathway | AKT1, ARL14EP, ATF7, ATP6AP1, CHD8, GNGT2, IP6K2, ITSN2 +10 more | View in SCUBA |
| Gamma-delta T cells | NK-like Mature gd-T cytotoxicity | ATG9A, CEP78, HAVCR2, HSH2D, IFIT2, ITGAX, KIR2DL1, KIR2DL3 +14 more | |
| Macrophages | Phagocytic Endolysosomal Lysosomal & pahgocytosis | ACTN4, AP3S1, ARF6, ATP6V1B2, CD151, CERS2, CNIH1, CPD +27 more | View in SCUBA |
| Smooth muscle cells | Secondary Response Genes Stress | BCL6, CSRNP1, ECM2, GADD45A, HRH2, LITAF, MAT2A, MCL1 +3 more | View in SCUBA |
About the gene
| Synonyms | LABH2 |
|---|---|
| Chromosome | 15: 89087459-89202355 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Enzymes, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Hydrolase, Serine esterase |
| Biological process | Lipid degradation, Lipid metabolism |
Function
Progesterone-dependent acylglycerol lipase that catalyzes hydrolysis of endocannabinoid arachidonoylglycerol (AG) from cell membrane. Acts as a progesterone receptor: progesterone-binding activates the acylglycerol lipase activity, mediating degradation of 1-arachidonoylglycerol (1AG) and 2- arachidonoylglycerol (2AG) to glycerol and arachidonic acid (AA). Also displays an ester hydrolase activity against acetyl ester, butanoate ester and hexadecanoate ester. Plays a key role in sperm capacitation in response to progesterone by mediating degradation of 2AG, an inhibitor of the sperm calcium channel CatSper, leading to calcium influx via CatSper and sperm activation. May also play a role in smooth muscle cells migration (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.