GNPDA1 — Glucosamine-6-phosphate deaminase 1
GNPDA1 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
GNPDA1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Monocytes | M2 Macrophage Polarization Tissue homeostasis | ABCC5, ADAP2, ARHGAP18, CD84, FRMD4B, LIPA, MAF, MRC1 | View in SCUBA |
| Mucosal-associated invariant T cell | Oxidative Stress Response Stress | CDC42EP3, CTU1, EXOSC5, GLRX, HTATIP2, KRCC1, MLX, MRPS6 +11 more |
About the gene
| Synonyms | GNPDA, GNPI, GPI, HLN, KIAA0060 |
|---|---|
| Chromosome | 5: 141991749-142013041 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Predicted intracellular proteins |
| Molecular function | Hydrolase, Isomerase |
| Biological process | Carbohydrate metabolism |
Function
Catalyzes the reversible conversion of alpha-D-glucosamine 6- phosphate (GlcN-6P) into beta-D-fructose 6-phosphate (Fru-6P) and ammonium ion, a regulatory reaction step in de novo uridine diphosphate-N-acetyl-alpha-D-glucosamine (UDP-GlcNAc) biosynthesis via hexosamine pathway. Deamination is coupled to aldo-keto isomerization mediating the metabolic flux from UDP-GlcNAc toward Fru-6P. At high ammonium level can drive amination and isomerization of Fru-6P toward hexosamines and UDP-GlcNAc synthesis. Has a role in fine tuning the metabolic fluctuations of cytosolic UDP-GlcNAc and their effects on hyaluronan synthesis that occur during tissue remodeling. Seems to trigger calcium oscillations in mammalian eggs. These oscillations serve as the essential trigger for egg activation and early development of the embryo (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.