CTU1 — Cytosolic thiouridylase subunit 1
CTU1 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CTU1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | T Cell Survival T cell maturation | CASP1, CCDC107, GEMIN7, GIMAP1, GIMAP2, GIMAP4, GIMAP5, GIMAP7 +13 more | |
| Mucosal-associated invariant T cell | Oxidative Stress Response Stress | CDC42EP3, EXOSC5, GLRX, GNPDA1, HTATIP2, KRCC1, MLX, MRPS6 +11 more |
About the gene
| Synonyms | ATPBD3, MGC17332, NCS6 |
|---|---|
| Chromosome | 19: 51097606-51108409 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | RNA-binding, Transferase, tRNA-binding |
| Biological process | tRNA processing |
Function
Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.