Oxidative Stress Response
Gene co-expression module in Mucosal-associated invariant T cell
| Category | Stress |
|---|---|
| Genes | 20 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 6 of 20 genes have a known function matching the annotation |
Why this annotation
PYCARD (ASC, inflammasome adaptor), PARP1 (DNA repair/damage sensor), GLRX (glutaredoxin, redox homeostasis), EXOSC5 (RNA exosome), CTU1 (tRNA thiolation), RASSF7 (Ras-association domain, stress signaling), HTATIP2 (tumor suppressor/oxidative stress). The combination of PYCARD+PARP1 suggests a genotoxic/oxidative stress response with inflammasome priming. GLRX adds redox stress context. The module is mixed but stress-associated genes predominate among the most biologically interpretable members.
Genes
CDC42EP3, CTU1, EXOSC5, GLRX, GNPDA1, HTATIP2, KRCC1, MLX, MRPS6, PARP1, PGLS, PHF23, PIN4, PPID, PREB, PYCARD, RASSF7, SARS1, SH3BGRL, UBXN11
Most correlated modules
- ER & Mitochondrial Assembly · correlation 0.90
- Mitochondrial Biogenesis · correlation 0.84
- T cell Homeostasis · correlation 0.83
- Mitochondrial Housekeeping · correlation 0.83
- T cell Identity · correlation 0.82
- MAIT Effector Maturation · correlation 0.77
- Chemokine Receptor Migration · correlation 0.76
- Leukocyte Housekeeping · correlation 0.76
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.