H1-5 — H1.5 linker histone, cluster member
H1-5 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
H1-5's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Replication-Coupled Histones Cell cycle | H2AC11, H2AC12, H2AC13, H2AC14, H2AC16, H3C2, LRR1 | |
| Monocytes | Mitotic Cell Cycle Cell cycle | BIRC5, CENPF, H2AC14, MKI67, PCLAF, PTTG1, STMN1, TROAP | View in SCUBA |
| Natural Killer cells | Replication Histones Cell cycle | H2AC11, H2AC12, H2AC16, H2AC20, H2BC9, H3C2, H3C4, H4C6 | View in SCUBA |
About the gene
| Synonyms | H1b, H1F5, H1s-3, HIST1H1B |
|---|---|
| Chromosome | 6: 27866792-27867588 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted intracellular proteins |
| Molecular function | DNA-binding |
Function
Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.