Replication-Coupled Histones
Gene co-expression module in Gamma-delta T cells
| Category | Cell cycle |
|---|---|
| Genes | 8 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 8 of 8 genes have a known function matching the annotation |
Why this annotation
All high-confidence hub genes are replication-dependent canonical histones: H2AC12, H2AC16, H2AC14, H2AC13 (H2A cluster histones), H3C2 (H3.1 replication-coupled histone), H1-5 (linker histone H1.5), H2AC11 (H2A histone). LRR1 (leucine-rich repeat protein 1, involved in replication licensing/CRL4 E3 ligase complex at replication origins). These histones are massively upregulated at S phase to package newly synthesized DNA. Core coherence across all members. The module sits in the cell-cycle neighborhood (M183, M83, M88) confirming this as a replication-coupled histone deposition program. Low mean expression (0.053) and 4.4% positive cells are consistent with the rare cycling subpopulation seen in other modules of this batch.
Genes
H1-5, H2AC11, H2AC12, H2AC13, H2AC14, H2AC16, H3C2, LRR1
Most correlated modules
- Mitosis Execution · correlation 0.93
- S-phase Replication · correlation 0.85
- Mitotic Spindle · correlation 0.81
- DNA Replication Licensing · correlation 0.70
- G1/S Entry · correlation 0.69
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.