Replication Histones
Gene co-expression module in Natural Killer cells
| Category | Cell cycle |
|---|---|
| Genes | 9 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 9 of 9 genes have a known function matching the annotation |
Why this annotation
All genes are core histone genes: H2AC16, H2AC12 (H2A variants), H3C4, H3C2 (H3 variants), H4C6 (H4), H1-5 (linker histone H1), H2AC11, H2BC9 (H2B), H2AC20. Replication-dependent histone gene expression is tightly coupled to S-phase DNA synthesis. This module represents the histone gene burst that accompanies DNA replication. It is a neighbor to M44 and M73 (S-phase modules), confirming the biological context. All delta values are 0, suggesting this module may be filtered or have no differential signal across conditions.
Genes
H1-5, H2AC11, H2AC12, H2AC16, H2AC20, H2BC9, H3C2, H3C4, H4C6
Most correlated modules
- Mitotic Spindle · correlation 0.84
- Replication-Coupled Histones · correlation 0.84
- S-phase Replication · correlation 0.83
- G2/M Transition · correlation 0.83
- DNA Replication · correlation 0.72
- Chromatin Remodeling · correlation 0.68
- Histone Variant Remodeling · correlation 0.68
- Mitochondrial Membrane Organization · correlation 0.37
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.