Natural Killer cells: gene co-expression modules
Cytotoxic innate lymphocytes lacking rearranged antigen receptors; integrate activating and inhibitory signals to kill stressed, virally infected, or MHC-low tumour cells and secrete interferon-gamma.
SCUBA's reference network for Natural Killer cells holds 88 gene modules covering 934 genes. Each module is a group of genes that rise and fall together across these cells, annotated with the biological process it most likely represents.
View the Natural Killer cells network in SCUBA
activation (9)
- AP-1 Immediate Early · 10 genes
- EGR2/3 NK Activation · 13 genes
- NK Activation Response · 8 genes
- NK Activation Signaling · 10 genes
- NK Activation Signaling · 8 genes
- NK Cell Activation · 9 genes
- NK Cell Activation · 11 genes
- NK Cell Activation · 11 genes
- NK Degranulation Activation · 12 genes
Cell cycle (7)
- DNA Replication · 9 genes
- G2/M Transition · 9 genes
- Mitotic Spindle · 12 genes
- Replication Histones · 9 genes
- Replication-Coupled Histones · 9 genes
- S-phase Replication · 8 genes
- S/G2M Cell Cycle · 9 genes
Cytoskeleton & motility (5)
- Actin Cytoskeleton Remodeling · 11 genes
- Actin Cytoskeleton Remodeling · 16 genes
- Cytoskeletal Remodeling · 13 genes
- NK Cytoskeletal Activation · 12 genes
- Septin Cytoskeletal Assembly · 9 genes
Cytotoxicity (8)
- Cytotoxic NK Maturation · 13 genes
- Granulysin Cytotoxic Effector · 9 genes
- ILC1/NK Cytotoxic · 13 genes
- Mature NK Identity · 9 genes
- NK Cytotoxic Activation · 12 genes
- NK Cytotoxic Activation · 10 genes
- NK Cytotoxic Signaling · 10 genes
- NK Cytotoxic Signaling · 12 genes
Differentiation (5)
- Mature NK Identity · 14 genes
- NK Cell Identity · 11 genes
- NK Cell Maturation · 9 genes
- NK Maturation Program · 11 genes
- NK/ILC Differentiation · 8 genes
DNA regulation & transcription (5)
- Chromatin Remodeling · 10 genes
- Histone Variant Remodeling · 11 genes
- Housekeeping Mixed · 10 genes
- TGF-beta Repression · 9 genes
- Transcription Elongation Control · 11 genes
Gut residency (7)
- Gut-Homing NK · 9 genes
- Gut-Homing NK Maturation · 14 genes
- ILC1-like NK Subset · 11 genes
- NK Tissue Residency · 8 genes
- Resident NK cells · 13 genes
- Resident NK program · 11 genes
- Tissue-Resident NK · 11 genes
Homing & TEM (3)
- Lymphocyte Trafficking · 12 genes
- NK Homing & Residency · 11 genes
- NK Homing Adhesion · 8 genes
Immune regulation (12)
- Cytokine Feedback Response · 9 genes
- Glucocorticoid Response · 20 genes
- Innate Sensing NK Regulation · 10 genes
- KIR+ NK Maturation · 12 genes
- NK Cell Exhaustion · 12 genes
- NK Checkpoint Receptors · 14 genes
- NK Homeostatic Survival · 10 genes
- NK Immune Checkpoint · 10 genes
- NK Lymphocyte Survival · 9 genes
- NK TGF-β Regulation · 10 genes
- TGF-beta Response · 11 genes
- TGF-β Antagonism · 10 genes
Inflammation (9)
- Circadian Innate Signaling · 10 genes
- Circadian NF-κB Crosstalk · 9 genes
- IFN-stimulated NK · 13 genes
- Immunoproteasome Activation · 9 genes
- Interferon NK Activation · 9 genes
- MAPK/AP-1 Signaling · 13 genes
- NF-κB Activation · 12 genes
- NF-κB Activation · 9 genes
- NK Inflammatory Activation · 10 genes
Metabolism (4)
- Cellular Homeostasis · 10 genes
- Energy Metabolism · 8 genes
- Glycolytic Metabolism · 11 genes
- Metabolic Activation · 11 genes
Mitochondrial & OxPhos (1)
- Mitochondrial Membrane Organization · 10 genes
RNA processing & translation (3)
- hnRNP RNA Processing · 8 genes
- mRNA Splicing · 10 genes
- Translation Elongation · 12 genes
Stress (10)
- Autophagy-Inflammation Stress · 12 genes
- Circadian Apoptotic Priming · 10 genes
- ER Stress Response · 9 genes
- Heat Shock Response · 12 genes
- Hypoxia Response · 11 genes
- Inducible HSP70 Stress · 11 genes
- Inflammatory Stress Response · 11 genes
- Integrated Stress Response · 10 genes
- NRF2 Stress Response · 11 genes
- Oxidative Stress Response · 11 genes