H2AC12 — H2A clustered histone 12
H2AC12 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
H2AC12's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Replication-Coupled Histones Cell cycle | H1-5, H2AC11, H2AC13, H2AC14, H2AC16, H3C2, LRR1 | |
| Natural Killer cells | Replication Histones Cell cycle | H1-5, H2AC11, H2AC16, H2AC20, H2BC9, H3C2, H3C4, H4C6 | View in SCUBA |
About the gene
| Synonyms | dJ86C11.1, H2A/S, H2AFALii, HIST1H2AH |
|---|---|
| Chromosome | 6: 27147106-27147562 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Essential proteins, Predicted intracellular proteins |
| Molecular function | DNA-binding |
Function
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.