LRR1 — Leucine rich repeat protein 1
LRR1 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
LRR1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD8⁺ T cells | Mitotic Spindle Assembly Cell cycle | FBXO5, MELK, MTFR2, NCAPG2, RAD51AP1, SHCBP1, SKA1, SKA3 +3 more | View in SCUBA |
| Gamma-delta T cells | Replication-Coupled Histones Cell cycle | H1-5, H2AC11, H2AC12, H2AC13, H2AC14, H2AC16, H3C2 |
About the gene
| Synonyms | LRR-1, MGC20689, PPIL5 |
|---|---|
| Chromosome | 14: 49598761-49614672 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Essential proteins, Predicted intracellular proteins |
| Biological process | Ubl conjugation pathway |
Function
Substrate recognition subunit of an ECS (Elongin BC-CUL2/5- SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. ECS(LRR1) ubiquitinates MCM7 and promotes CMG replisome disassembly by VCP and chromatin extraction during S- phase (By similarity). May negatively regulate the 4-1BB-mediated signaling cascades which result in the activation of NK-kappaB and JNK1.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.