H2AC25 — H2A clustered histone 25
H2AC25 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
H2AC25's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Macrophages | MMP-driven ECM Remodeling ECM remodeling | A4GALT, ACP5, ASB2, ASMTL, ATP6V0D2, BID, CFP, CPOX +12 more | View in SCUBA |
| Monocytes | Myeloid Epigenetic Regulation Developmental | CYRIA, GPRC5A, MN1, MTHFD1L, PCGF5, PDE2A, PPP1R14B, RAPH1 +1 more | View in SCUBA |
About the gene
| Synonyms | H2AW, HIST3H2A, MGC3165 |
|---|---|
| Chromosome | 1: 228434777-228457873 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Essential proteins, Plasma proteins, Predicted intracellular proteins |
| Molecular function | DNA-binding |
Function
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.