HENMT1 — HEN methyltransferase 1
HENMT1 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
HENMT1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | DNA Damage Repair DNA/chromatin regulation | AGGF1, ANP32A, DCK, DDX46, HADHA, HDDC2, IFNAR1, LYPLA1 +8 more |
About the gene
| Synonyms | C1orf59, FLJ30525, HEN1 |
|---|---|
| Chromosome | 1: 108648290-108661526 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Predicted intracellular proteins |
| Molecular function | Methyltransferase, RNA-binding, Transferase |
| Biological process | RNA-mediated gene silencing |
Function
Methyltransferase that adds a 2'-O-methyl group at the 3'-end of piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. This probably protects the 3'-end of piRNAs from uridylation activity and subsequent degradation. Stabilization of piRNAs is essential for gametogenesis
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.