DNA Damage Repair
Gene co-expression module in Gamma-delta T cells
| Category | DNA/chromatin regulation |
|---|---|
| Genes | 17 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 17 genes have a known function matching the annotation |
Why this annotation
Hub genes XRCC5 (Ku80), RECQL, and XRCC1 are canonical DNA repair proteins. XRCC5/Ku80 is the core component of the Ku heterodimer that initiates non-homologous end joining (NHEJ) of DNA double-strand breaks. RECQL is a RecQ-family DNA helicase involved in DNA unwinding at stalled replication forks and DSB repair. XRCC1 is a scaffold protein in base excision repair (BER). UCHL5 is a deubiquitinase associated with the proteasome and the INO80 chromatin remodeling complex involved in DNA damage response. DDX46 is an RNA helicase involved in splicing, potentially relevant to splicing of DNA repair factor transcripts. TCEA1 (TFIIS) promotes transcription-coupled repair. ANP32A participates in chromatin regulation during DNA damage. DCK (deoxycytidine kinase) supports nucleotide pools for repair synthesis. HADHA and IFNAR1 are more peripheral. The DNA repair theme is strongly supported by multiple independent repair pathway members.
Genes
AGGF1, ANP32A, DCK, DDX46, HADHA, HDDC2, HENMT1, IFNAR1, LYPLA1, PSME3IP1, RECQL, TCEA1, TMOD3, TOR3A, UCHL5, XRCC1, XRCC5
Most correlated modules
- mRNA Splicing · correlation 0.89
- Interferon Stimulated Response · correlation 0.84
- Complex I Assembly · correlation 0.81
- Mitoribosome Small Subunit · correlation 0.81
- Actin Remodeling · correlation 0.81
- Endosomal Vesicle Trafficking · correlation 0.81
- Cellular Homeostasis · correlation 0.80
- Rho GTPase Signaling · correlation 0.79
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.