LYPLA1 — Lysophospholipase 1
LYPLA1 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
LYPLA1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Chromatin Regulation DNA/chromatin regulation | BIK, DSTN, GCHFR, GRHPR, HDAC1, HMGN1, IMP4, METAP2 +3 more | View in SCUBA |
| CD4⁺ T cells | Lipid Metabolism Housekeeping | ANXA7, AP2B1, ASNSD1, C1D, CAPZA2, ECHDC1, EIF3A, GRSF1 +3 more | View in SCUBA |
| Gamma-delta T cells | DNA Damage Repair DNA/chromatin regulation | AGGF1, ANP32A, DCK, DDX46, HADHA, HDDC2, HENMT1, IFNAR1 +8 more | |
| Innate lymphoid cells | Lipid & Isoprenoid Metabolism Metabolism | ARL6IP1, CHCHD5, ECH1, FDPS, GTF2H5, NECAP2, NUBP2, OCIAD2 +8 more | View in SCUBA |
| Macrophages | Nuclear Pore Transport Housekeeping | AARS1, APH1A, ARF3, ATG3, CNOT7, CTDNEP1, DCAF7, GNAI2 +18 more | View in SCUBA |
| Smooth muscle cells | Actin Cytoskeletal Scaffold Cytoskeletal | ACTN4, ATP2B4, ATRX, DDX5, DLGAP4, EIF4G2, FAT1, GNAI2 +13 more | View in SCUBA |
About the gene
| Synonyms | APT-1, LPL1 |
|---|---|
| Chromosome | 8: 54046367-54102017 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Hydrolase |
| Biological process | Fatty acid metabolism, Lipid metabolism |
Function
Acts as an acyl-protein thioesterase. Hydrolyzes fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS. Acts as a palmitoyl thioesterase that catalyzes depalmitoylation of proteins, such as ADRB2, KCNMA1 and SQSTM1. Acts as a negative regulator of autophagy by mediating palmitoylation of SQSTM1, decreasing affinity between SQSTM1 and ATG8 proteins and recruitment of ubiquitinated cargo proteins to autophagosomes. Acts as a lysophospholipase and hydrolyzes lysophosphatidylcholine (lyso-PC). Also hydrolyzes lysophosphatidylethanolamine (lyso- PE), lysophosphatidylinositol (lyso-PI) and lysophosphatidylserine (lyso-PS) (By similarity). Has much higher thioesterase activity than lysophospholipase activity. Contributes to the production of lysophosphatidic acid (LPA) during blood coagulation by recognizing and cleaving plasma phospholipids to generate lysophospholipids which in turn act as substrates for ENPP2 to produce LPA.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.