DDX46 — DEAD-box helicase 46
DDX46 belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
DDX46's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | mRNA splicing RNA processing | ANAPC5, C11orf58, C1orf43, DNAJC7, HSPA4, LSM14A, LUC7L3, MRPL47 +8 more | View in SCUBA |
| CD8⁺ T cells | Epigenetic Chromatin Maintenance DNA/chromatin regulation | BAZ1B, DNMT1, HNRNPAB, NASP, NOP56, SET, SMC1A, SMC3 +2 more | View in SCUBA |
| Endothelial | Endothelial NO Activation Endothelial cell development | BCL6B, BLOC1S1, CD99, CDH13, COX5A, CREM, DDAH2, EEA1 +8 more | View in SCUBA |
| Gamma-delta T cells | DNA Damage Repair DNA/chromatin regulation | AGGF1, ANP32A, DCK, HADHA, HDDC2, HENMT1, IFNAR1, LYPLA1 +8 more | |
| Innate lymphoid cells | Pre-mRNA Splicing RNA processing & translation | AAK1, CDC42SE2, CIB1, HNRNPM, KRT10, KTN1, LARP7, LYRM2 +3 more | View in SCUBA |
| Macrophages | Protein Biogenesis Housekeeping | ATP6V0D1, B3GAT3, BUD23, C11orf58, CHD4, CNPY2, DAZAP1, DNAJA2 +23 more | View in SCUBA |
| Mucosal-associated invariant T cell | Integrin Actin Adhesion migration & adhesion | ACTR2, ANKRD10, ATP2B1, HP1BP3, HPS3, JAK1, LINS1, LRIF1 +11 more |
About the gene
| Synonyms | FLJ25329, KIAA0801, Prp5, PRPF5 |
|---|---|
| Chromosome | 5: 134758771-134855133 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Enzymes, Essential proteins, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Helicase, Hydrolase, RNA-binding |
| Biological process | mRNA processing, mRNA splicing |
Function
Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs. The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing. Within the 17S U2 SnRNP complex, DDX46 plays essential roles during assembly of pre-spliceosome and proofreading of the branch site.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.