ANP32A — Acidic nuclear phosphoprotein 32 family member A

ANP32A belongs to a gene co-expression module in 9 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

ANP32A's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	RNA Processing RNA processing	CCDC167, CDK4, CENPX, CYC1, FDPS, GGCT, LSM3, LSM4 +14 more	View in SCUBA
CD4⁺ T cells	Oxidative Phosphorylation Mitochondrial & OxPhos	ATP5F1A, ATP5F1B, COX7A2, COX7B, GADD45GIP1, GNG5, MRPL21, MRPS16 +10 more	View in SCUBA
CD8⁺ T cells	RNA & Redox Housekeeping RNA processing & translation	C11orf58, CCT6A, COPRS, DPM2, GGCT, GLRX3, LAGE3, NME1 +3 more	View in SCUBA
Gamma-delta T cells	DNA Damage Repair DNA/chromatin regulation	AGGF1, DCK, DDX46, HADHA, HDDC2, HENMT1, IFNAR1, LYPLA1 +8 more
Goblet cells	Chromatin RNA Regulation chromatin regulation & transcription	CBX1, HDAC2, HNRNPA0, HNRNPM, KHDRBS1, NONO, RBMX, RCN2 +1 more	View in SCUBA
Innate lymphoid cells	Mitochondrial Metabolism Mitochondrial & OxPhos	ACTR10, APOL3, ATP6V1E1, ECHS1, ERCC1, ETFB, GLRX3, HIGD1A +12 more	View in SCUBA
Macrophages	Complex I / NADH Dehydrogenase Mitochondrial & OxPhos	AHCY, ANTKMT, APEX1, ARL2, ATIC, ATP5F1A, ATP5ME, CCDC85B +31 more	View in SCUBA
Mucosal-associated invariant T cell	Cellular Housekeeping Housekeeping	AKR7A2, ANXA5, AP1M1, APEX1, APOBEC3C, CDC26, DBNL, DCK +17 more
Neutrophils	Myeloid Identity Housekeeping	CKLF, CMTM2, HLA-C, HLA-E, IFITM2, ITM2B, LST1, MYL12A +3 more

About the gene

Synonyms	C15orf1, I1PP2A, LANP, MAPM, mapmodulin, PHAPI, PP32
Chromosome	15: 68778535-68820897
Predicted location	Intracellular
Essential gene	No
Protein class	Plasma proteins, Predicted intracellular proteins
Molecular function	Repressor
Biological process	Host-virus interaction, Transcription, Transcription regulation

Function

Multifunctional protein that is involved in the regulation of many processes including tumor suppression, apoptosis, cell cycle progression or transcription. Promotes apoptosis by favouring the activation of caspase-9/CASP9 and allowing apoptosome formation. In addition, plays a role in the modulation of histone acetylation and transcription as part of the INHAT (inhibitor of histone acetyltransferases) complex. Inhibits the histone- acetyltranferase activity of EP300/CREBBP (CREB-binding protein) and EP300/CREBBP-associated factor by histone masking. Preferentially binds to unmodified histone H3 and sterically inhibiting its acetylation and phosphorylation leading to cell growth inhibition. Participates in other biochemical processes such as regulation of mRNA nuclear-to-cytoplasmic translocation and stability by its association with ELAVL1 (Hu-antigen R). Plays a role in E4F1-mediated transcriptional repression as well as inhibition of protein phosphatase 2A. (Microbial infection) Plays an essential role in influenza A, B and C viral genome replication. Mechanistically, mediates the assembly of the viral replicase asymmetric dimers composed of PB1, PB2 and PA via its N-terminal region. Also plays an essential role in foamy virus mRNA export from the nucleus.

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.