HS6ST1 — Heparan sulfate 6-O-sulfotransferase 1
HS6ST1 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
HS6ST1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | Heparan Sulfate Remodeling ECM remodeling | ALDH1A3, COL12A1, FAM171B, FANCC, FHOD3, GREB1, JMJD1C, MAP1LC3A +11 more | View in SCUBA |
About the gene
| Synonyms | HS6ST |
|---|---|
| Chromosome | 2: 128236716-128318868 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Disease related genes, Essential proteins, Human disease related genes, Metabolic proteins, Predicted intracellular proteins |
| Molecular function | Transferase |
Function
6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate. Critical for normal neuronal development where it may play a role in neuron branching. May also play a role in limb development. May prefer iduronic acid.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.