COL12A1 — Collagen type XII alpha 1 chain
COL12A1 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
COL12A1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | Heparan Sulfate Remodeling ECM remodeling | ALDH1A3, FAM171B, FANCC, FHOD3, GREB1, HS6ST1, JMJD1C, MAP1LC3A +11 more | View in SCUBA |
| Glial cells | Enteric Glial Homeostasis Housekeeping | APOE, BCHE, CCND3, ENTPD2, FXYD6, NPDC1, PAQR6, PCSK1N +5 more | View in SCUBA |
| Pericytes | Fibrotic ECM Remodeling ECM remodeling | ADAMTS12, ADAMTS2, CD248, COL5A2, FSTL1, LOXL2, NID2, PAMR1 +2 more | View in SCUBA |
| Smooth muscle cells | Mesenchymal Adhesion Program Migration & adhesion | ANTXR1, BAG2, CDH11, CTSB, FHL3, FSTL3, HEPH, PIM1 +6 more | View in SCUBA |
About the gene
| Synonyms | COL12A1L |
|---|---|
| Chromosome | 6: 75084326-75206267 |
| Predicted location | Intracellular, Secreted |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins |
| Biological process | Cell adhesion |
Function
Type XII collagen interacts with type I collagen-containing fibrils, the COL1 domain could be associated with the surface of the fibrils, and the COL2 and NC3 domains may be localized in the perifibrillar matrix
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.