Heparan Sulfate Remodeling
Gene co-expression module in Fibroblasts
| Category | ECM remodeling |
|---|---|
| Genes | 20 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 20 genes have a known function matching the annotation |
Why this annotation
SULF1 (heparan sulfate 6-O-endosulfatase that modulates growth factor gradients by editing heparan sulfate proteoglycans) is the top hub gene. HS6ST1 (heparan sulfate 6-O-sulfotransferase) is also present, forming a coherent heparan sulfate modification program. WWTR1 (TAZ, Hippo pathway effector) and FHOD3 (formin, actin cytoskeleton) suggest mechanosensing context. COL12A1 (fibril-associated collagen), TNC (tenascin-C, ECM glycoprotein upregulated in remodeling), and THBD (thrombomodulin, anti-coagulant/anti-inflammatory endothelial/stromal marker) add ECM remodeling character. ALDH1A3 (retinoic acid synthesis) and TSHZ3 (transcription factor) contribute to stromal identity. The module is a neighbor of M48 (TGF-β/ECM), reinforcing an ECM remodeling neighborhood. Divergent disease responses (decreased in UC inflammation, increased in CD inflammation) suggest context-dependent regulation.
Genes
ALDH1A3, COL12A1, FAM171B, FANCC, FHOD3, GREB1, HS6ST1, JMJD1C, MAP1LC3A, NXN, SDK1, SGCD, SORCS2, SPATS2L, SULF1, THBD, TMEM200A, TNC, TSHZ3, WWTR1
Most correlated modules
- Metabolic Homeostasis · correlation 0.84
- ECM Glycan Remodeling · correlation 0.78
- Myofibroblast Subtype · correlation 0.75
- TGF-beta Response · correlation 0.75
- Thrombin Receptor Signaling · correlation 0.75
- Adventitial Fibroblast State · correlation 0.71
- Caveolae Mechanosensing · correlation 0.71
- Fibroblast Niche Identity · correlation 0.66
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.