SCUBA

JMJD1C — Jumonji domain containing 1C

JMJD1C belongs to a gene co-expression module in 10 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

JMJD1C's module in each cell type

Cell typeModuleShares the module with
CD19⁺ B cellsChromatin Modification
DNA/chromatin regulation
AKAP13, CREBRF, EPC1, GCC2, GPBP1, KMT2E, OFD1, PPP1R2 +6 moreView in SCUBA
CD4⁺ T cellsTranscriptional regulation
DNA/chromatin regulation
CCNH, CWC25, DYNLL2, EIF2A, GOLGB1, IVNS1ABP, KRR1, LPIN2 +8 moreView in SCUBA
EnterocytesColonocyte differentiation TFs
Chromatin regulation & transcription
AGAP1, ATXN1, DENND1B, DOCK5, GOLIM4, GRAMD2B, HNF4G, LCORL +7 moreView in SCUBA
FibroblastsHeparan Sulfate Remodeling
ECM remodeling
ALDH1A3, COL12A1, FAM171B, FANCC, FHOD3, GREB1, HS6ST1, MAP1LC3A +11 moreView in SCUBA
Gamma-delta T cellsChromatin Epigenetic Regulation
DNA/chromatin regulation
ADNP2, ARID4B, CEBPZ, ELL2, ENSG00000285976, ETF1, HIPK1, JMY +17 more
Innate lymphoid cellsActin Cytoskeleton Dynamics
Cytoskeleton & motility
ACTN4, ALDH9A1, APBB1IP, ARHGAP10, CDC37, CXXC5, FAM136A, FERMT3 +26 moreView in SCUBA
Lymphatic endothelialChromatin Remodeling
DNA/chromatin regulation
BAZ2B, CHD9, ITFG1, MICAL3, MPDZ, PACSIN2, PHKB, PLXDC2 +4 moreView in SCUBA
MacrophagesEpigenetic Remodeling
Housekeeping
AFF4, AGO3, AKAP13, ARID4B, ASH1L, CYTH1, ELF1, EPC1 +16 moreView in SCUBA
Mucosal-associated invariant T cellSTAT4 T cell Identity
T cell maturation
ATF7IP, CAMK4, CBLB, CD96, CELF2, DENND4A, IKZF1, PIP4K2A +7 more
NeutrophilsKLF2 Survival Response
Stress
BEST1, FOSB, IDS, KLF2, KLF6, MYADM, RASSF5, YPEL5 +1 more

About the gene

SynonymsDKFZp761F0118, FLJ14374, KDM3C, KIAA1380, TRIP8
Chromosome10: 63167221-63521850
Predicted locationIntracellular
Essential geneNo
Protein classPredicted intracellular proteins
Molecular functionChromatin regulator, Dioxygenase, Oxidoreductase
Biological processTranscription, Transcription regulation

Function

Probable histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May be involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes (By similarity)

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.