IGF2BP2 — Insulin like growth factor 2 mRNA binding protein 2
IGF2BP2 belongs to a gene co-expression module in 1 of 30 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
IGF2BP2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Colonocytes | Actin-Motor Organization Cytoskeletal | ACTR2, AKAP9, CAMK2D, DYNC1H1, DYNC1LI2, GOLGB1, LIMA1, MBNL1 +8 more | View in SCUBA |
About the gene
| Synonyms | IMP-2, p62 |
|---|---|
| Chromosome | 3: 185643130-185825042 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Human disease related genes, Plasma proteins, Predicted intracellular proteins |
| Molecular function | RNA-binding |
| Biological process | mRNA transport, Translation regulation, Transport |
Function
RNA-binding factor that recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation (By similarity). Preferentially binds to N6-methyladenosine (m6A)-containing mRNAs and increases their stability. Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs. Binding is isoform- specific. Binds to beta-actin/ACTB and MYC transcripts. Increases MYC mRNA stability by binding to the coding region instability determinant (CRD) and binding is enhanced by m6A-modification of the CRD.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.