DYNC1LI2 — Dynein cytoplasmic 1 light intermediate chain 2
DYNC1LI2 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
DYNC1LI2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Membrane Trafficking Protein processing & ER | B4GALT1, BTF3L4, CELF1, CLTC, CSNK1G3, CTBS, DERL2, EMC9 +23 more | View in SCUBA |
| Endothelial | WAVE Complex Cytoskeleton Cytoskeletal | ATP2B4, C6orf89, CD46, CYFIP1, GIT1, GNB1, IQGAP1, MAP7D1 +3 more | View in SCUBA |
| Goblet cells | Adhesion & Transport Cytoskeletal | AHCYL1, CHMP1B, DDX5, DYNC1H1, EIF4G2, ITGB1, PTTG1IP, SLC38A1 +4 more | View in SCUBA |
| Macrophages | Chromatin Transcriptional Regulation Housekeeping | AGO1, ARID1A, CARD8, CEPT1, CLOCK, CPSF7, CTNND1, DCAF10 +19 more | View in SCUBA |
About the gene
| Synonyms | DNCLI2 |
|---|---|
| Chromosome | 16: 66720893-66751609 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | Motor protein |
| Biological process | Transport |
Function
Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.