DYNC1H1 — Dynein cytoplasmic 1 heavy chain 1
DYNC1H1 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
DYNC1H1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Transcription-RNA Coupling DNA/chromatin regulation | AKNA, AP1G1, BTAF1, BZW1, CRNKL1, DDX6, DNTTIP2, EDRF1 +26 more | |
| Glial cells | Glial RNA Homeostasis RNA processing & translation | ATRX, GTF2I, NCL, RBM25, SCN9A, SRSF11, SYNM | View in SCUBA |
| Goblet cells | Adhesion & Transport Cytoskeletal | AHCYL1, CHMP1B, DDX5, DYNC1LI2, EIF4G2, ITGB1, PTTG1IP, SLC38A1 +4 more | View in SCUBA |
| Macrophages | ER-Golgi Trafficking Vesicular traficking | ADD1, AFTPH, AZIN1, COPA, HNRNPC, JOSD1, LCP2, LRRFIP1 +23 more | View in SCUBA |
| Mucosal-associated invariant T cell | Cytoskeletal Organization Cytoskeletal | ARAP2, CHD8, CTNNB1, EP400, NFATC2, RASSF2, RNF4, SRPRA +4 more |
About the gene
| Synonyms | CMT2O, DHC1, DNCH1, Dnchc1, DNCL, DNECL, HL-3, p22 |
|---|---|
| Chromosome | 14: 101964573-102056443 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Disease related genes, Essential proteins, Human disease related genes, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Motor protein |
| Biological process | Cell cycle, Cell division, Mitosis, Transport |
Function
Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Plays a role in mitotic spindle assembly and metaphase plate congression
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.