LIMA1 — LIM domain and actin binding 1
LIMA1 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
LIMA1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | MAF regulatory program Immune regulation | AKAP13, ARID4B, DTHD1, FYN, IKZF3, ISCU, LIMS1, MAF +12 more | View in SCUBA |
| Endothelial | Hypoxia-IFN Endothelial Endothelial cell development | BCAM, CRIP2, EPAS1, FES, HEG1, IFI27, IFITM1, LIMS2 +8 more | View in SCUBA |
| Enterocytes | Serotonergic receptor signaling Secretion | HTR4, KCNQ3, LAMB1, NECTIN3, NFIB, TBC1D32 | View in SCUBA |
| Fibroblasts | Inflammation-activated ECM ECM remodeling | AKR1C1, COL4A3, COL4A4, COL8A1, FAM107B, MAPKAP1, MEDAG, PTHLH +2 more | View in SCUBA |
| Macrophages | Lysosomal Hydrolase Program Lysosomal & pahgocytosis | AMDHD2, ARL6IP5, ARPIN, ARSA, CD81, CLDN7, CLEC2B, COMT +35 more | View in SCUBA |
| Smooth muscle cells | Hypoxia-NRF2 Activation Stress | IL1R1, MYADM, NFE2L2, REV3L, SERPINH1, UPF3A, VEGFA, ZEB2 | View in SCUBA |
About the gene
| Synonyms | EPLIN |
|---|---|
| Chromosome | 12: 50175788-50283520 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | Actin-binding |
| Biological process | Cholesterol metabolism, Lipid metabolism, Steroid metabolism, Sterol metabolism |
Function
Actin-binding protein involved in actin cytoskeleton regulation and dynamics. Increases the number and size of actin stress fibers and inhibits membrane ruffling. Inhibits actin filament depolymerization. Bundles actin filaments, delays filament nucleation and reduces formation of branched filaments. Acts as a negative regulator of primary cilium formation. Plays a role in cholesterol homeostasis. Influences plasma cholesterol levels through regulation of intestinal cholesterol absorption. May act as a scaffold protein by regulating NPC1L1 transportation, an essential protein for cholesterol absorption, to the plasma membrane by recruiting MYO5B to NPC1L1, and thus facilitates cholesterol uptake (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.