AKAP9 — A-kinase anchoring protein 9
AKAP9 belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
AKAP9's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Chromatin Regulation DNA/chromatin regulation | ANKRD12, BBX, CHD2, CHD7, IRF1, KDM7A, L3MBTL3, MAP3K1 +8 more | View in SCUBA |
| Gamma-delta T cells | Centrosome Organization DNA/chromatin regulation | ARMCX6, CCNT2, CEP350, CUL5, DDHD1, DDX42, DENND6A, DMTF1 +23 more | |
| Glial cells | Glial Adhesion Cytoskeletal migration & adhesion | COL21A1, DOCK5, EPB41L2, KIAA1217, LTBP3, NCAM1, RALGPS2, SCN7A +1 more | View in SCUBA |
| Innate lymphoid cells | Centrosome & Scaffolding Cytoskeleton & motility | APPL1, ARID4A, CCDC91, CPNE3, ETNK1, FAM204A, GOPC, LRBA +14 more | View in SCUBA |
| Macrophages | DNA Damage Repair Stress | ABCC5, ADAM28, AKNA, ATM, ATP10D, BAZ2A, CHD9, CREBRF +27 more | View in SCUBA |
| Mucosal-associated invariant T cell | TGF-β Immune Regulation Immune regulation | ADAM12, AFF1, FNBP4, IKZF3, INPP4A, MAN1A1, NSD3, PCNX1 +8 more | |
| Natural Killer cells | NK Cell Activation activation | AKIRIN1, ALG13, DDX24, EIF1AX, ETF1, EZR, GNL3, PPP1CB +2 more | View in SCUBA |
About the gene
| Synonyms | AKAP350, AKAP450, CG-NAP, HYPERION, KIAA0803, LQT11, MU-RMS-40.16A, PPP1R45, PRKA9, YOTIAO |
|---|---|
| Chromosome | 7: 91940840-92110673 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins |
Function
Scaffolding protein that assembles several protein kinases and phosphatases on the centrosome and Golgi apparatus. Required to maintain the integrity of the Golgi apparatus. Required for microtubule nucleation at the cis-side of the Golgi apparatus. Required for association of the centrosomes with the poles of the bipolar mitotic spindle during metaphase. In complex with PDE4DIP isoform 13/MMG8/SMYLE, recruits CAMSAP2 to the Golgi apparatus and tethers non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement. In complex with PDE4DIP isoform 13/MMG8/SMYLE, EB1/MAPRE1 and CDK5RAP2, contributes to microtubules nucleation and extension also from the centrosome to the cell periphery. Associated with the N-methyl-D-aspartate receptor and is specifically found in the neuromuscular junction (NMJ) as well as in neuronal synapses, suggesting a role in the organization of postsynaptic specializations
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.