Actin-Motor Organization
Gene co-expression module in Colonocytes
| Category | Cytoskeletal |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 11 of 17 genes have a known function matching the annotation |
Why this annotation
Hub gene ACTR2 (ARP2, actin-related protein 2, nucleates branched actin networks) is the top-ranked gene. DYNC1H1 and DYNC1LI2 (cytoplasmic dynein heavy and light intermediate chains, minus-end directed motor), LIMA1/EPLIN (actin bundling and stabilization), SHROOM3 (apical actin organization, epithelial morphology), SPTAN1 (alpha-spectrin, cortical cytoskeleton), MYO1C (myosin Ic, membrane tension), and AKAP9 (A-kinase anchoring protein, centrosome/Golgi) define a broad cytoskeletal organization module. CAMK2D (calcium/calmodulin kinase II delta) and PHACTR2 (phosphatase and actin regulator) link calcium signaling to actin dynamics. GOLGB1 (giantin, Golgi structural protein) and SLC35A3 (UDP-GlcNAc Golgi transporter) add Golgi organization. This module is a topological neighbor of M109 (inflammatory cytoskeletal remodeling) but lacks the inflammation signal, suggesting it represents constitutive cytoskeletal/motor organization in colonocytes.
Genes
Most correlated modules
- Fatty Acid Oxidation · correlation 0.81
- ER Stress & Trafficking · correlation 0.78
- Senescent Colonocyte Transcription · correlation 0.76
- Inflammatory Cytoskeletal Remodeling · correlation 0.74
- Cellular Senescence · correlation 0.74
- Colonocyte Senescence · correlation 0.74
- Ubiquitin-Proteasome System · correlation 0.72
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.