IGHA2 — Immunoglobulin heavy constant alpha 2 (A2m marker)
IGHA2 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
IGHA2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | IgA plasma cell B cell maturation | AIM2, CD27, CORO1B, IGHA1, JCHAIN, MGAT4A, OSBPL10, RASSF6 +2 more | View in SCUBA |
| Monocytes | Tissue-Resident Macrophage Tissue adaptation | ALDH1A1, CPED1, DAAM2, EIF4B, FN1, H2AC19, HDAC9, LPL +3 more | View in SCUBA |
About the gene
| Chromosome | 14: 105583731-105588395 |
|---|---|
| Predicted location | Intracellular, Membrane, Secreted |
| Essential gene | No |
| Protein class | Immunoglobulin genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins |
| Biological process | Adaptive immunity, Immunity |
Function
Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins- secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens. The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen. Ig alpha is the major immunoglobulin class in body secretions.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.