OSBPL10 — Oxysterol binding protein like 10
OSBPL10 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
OSBPL10's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | IgA plasma cell B cell maturation | AIM2, CD27, CORO1B, IGHA1, IGHA2, JCHAIN, MGAT4A, RASSF6 +2 more | View in SCUBA |
About the gene
| Chromosome | 3: 31657912-32077580 |
|---|---|
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Biological process | Lipid biosynthesis, Lipid metabolism, Lipid transport, Transport |
Function
Probable lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane. Its ability to bind phosphatidylserine, suggests that it specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P (Probable). Plays a role in negative regulation of lipid biosynthesis. Negatively regulates APOB secretion from hepatocytes. Binds cholesterol and acidic phospholipids. Also binds 25- hydroxycholesterol. Binds phosphatidylserine.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.