IKBKG — Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma
IKBKG belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
IKBKG's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Lymphocyte Homeostatic Regulation Housekeeping | BSG, CTDSP1, FBXW5, HMGN4, IGSF8, LRP10, MFNG, RASAL3 +8 more |
About the gene
| Synonyms | FIP-3, FIP3, Fip3p, IKK-gamma, IKKAP1, IKKG, IP1, IP2, NEMO, ZC2HC9 |
|---|---|
| Chromosome | X: 154541199-154565046 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Predicted intracellular proteins, RAS pathway related proteins |
| Biological process | DNA damage, Host-virus interaction, Transcription, Transcription regulation |
Function
Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Its binding to scaffolding polyubiquitin plays a key role in IKK activation by multiple signaling receptor pathways. Can recognize and bind both 'Lys-63'-linked and linear polyubiquitin upon cell stimulation, with a much higher affinity for linear polyubiquitin. Could be implicated in NF-kappa-B-mediated protection from cytokine toxicity. Essential for viral activation of IRF3. Involved in TLR3- and IFIH1-mediated antiviral innate response; this function requires 'Lys- 27'-linked polyubiquitination. (Microbial infection) Also considered to be a mediator for HTLV-1 Tax oncoprotein activation of NF-kappa-B
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.